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  2. #142

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  10. #150
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    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322589/
    Currently, there is no effective medical therapy for PSC. Ursodexoycholic acid (UDCA) is the single most extensively studied agent in PSC. Several controlled and uncontrolled clinical trials have shown significant improvement in liver biochemistries when PSC patients were treated with UDCA (1015). However, large randomized and controlled prospective clinical trials have failed to demonstrate that UDCA can positively affect the clinical outcomes of patients with PSC (13,15). In fact, the safety of long term use of high-dose UDCA in PSC patients has been questioned, as it has been associated with increased rates of serious adverse events (13,16) and, more recently, with the development of colon cancer (16,17). The American Association for the Study of Liver Disease (AASLD) recommends against the use of UDCA in PSC patients (7). Liver transplantation remains the treatment of choice for end-stage PSC, being the fifth leading indication for liver transplantation in the United States (18). In some Scandinavian countries, PSC is the leading indication for liver transplantation (1820). Recurrent PSC is an important problem, occurring in the transplanted liver in 20%40% of PSC patients (18).

    Doctor, please, give me a dose of the American Dream
    Put down the pen and look in my eyes
    We're in the waiting room and something ain't right
    All this is on you, we're over prescribed
    , 25.11.2016 14:45
       

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