1 4 4

:

  1. #1
      turist
    08.12.2016
    34
    100

    !
    - .
    ( ) ?

  2. #2
      turist
    08.12.2016
    34
    100

    https://ibdnewstoday.com/filgotinib-crohns-disease/


    JAK1 (Janus kinase 1). JAK1 - , , , , .

    CD. , - - . , -, .

    Filgotinib
    , CD , .

    2 FITZROY (NCT02048618) 174 CD .

    200 , 10 . , CD (CDAI), 150 10 . 100, 200 10 .

    128 , 200 , 60 (47 ) 10 , 10 44 , (23 ), .

    CD.

    (NCT03077412) CD . 2 - 24 . - 2019 .

    2, , CD . , 24 . - 2019 .

    3 (NCT02914600), , , . , , 144 30 . , , 2022 .

  3. #3
      turist
    08.12.2016
    34
    100




    Filgotinib JAK1 . , JAK1. JAK (, tofacitinib) . . , [1]. , JAK . -JAK- , . , .

    JAK1. JAK2 RA. , JAK2 - . , JAK1 . Filgotinib 30- JAK1 JAK2. [2] , , JAK2.


    Phase2b ( DARWIN 1, 2) 886 180 .

    1
    1 , CYP450. . - [3].

    2: (2011)
    2011 2 (: NCT01384422, Eudract: 2010-022953-40), 36 , [4]. 200 , 200 . ACR20, . 4 83% ACR20. ( ) . . -, filgotinib JAK1, . , GLPG0634 , - [5].

    DARWIN 1
    DARWIN 1 24- - 599 . . . [6] . 2015 , 2015 . [7] [8] Galapagos , , ARC70 39% . [8] [9]

    DARWIN 2
    DARWIN 2 - 280 , . DARWIN 1 . [10]. DARWIN- 2b 2014 . [11] 2015 , . [12]

    DARWIN 3
    , DARWIN 1 2, DARWIN 3. 2017 84- [13]. - 2019. [14]

    3 FINCH
    FINCH 1 , (MTX) . / Humira [15]. FINCH 2 , . FINCH 3 , , .


    - MANTA [16]. , FDA 200 III FINCH [17].

  4. #4
      Serj
    , totale Niederlage
    12.08.2012
    .
    40
    191

    , , .
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,

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