Naltrexone

[Вася Пупкин]

На примере кодеина, его влияние на определенные болезни и опиоидные рецепторы, используемые оф.медициной! А также использование налтрексона при передозах кодеина!
( Вики) Кодеин
Кодеин — 3-метилморфин, алкалоид опиума, используется как противокашлевое лекарственное средство центрального действия, обычно в сочетании с другими веществами,
Анальгетическая активность обусловлена возбуждением опиатных рецепторов в различных отделах центральной нервной системы и периферических тканях, приводящим к стимуляции антиноцицептивной системы и изменению эмоционального восприятия боли.
Реже вызывает запоры (активация опиоидных рецепторов в кишечнике вызывает расслабление гладких мышц, снижение перистальтики и спазм всех сфинктеров).
Алкалоид, содержащийся в опии (0,2 - 2% в опии Papaver Somniferum); получается также полусинтетическим путём - метилированием морфина.

По характеру действия кодеин близок к морфину, но болеутоляющие свойства выражены слабее; сильно выражена способность уменьшать возбудимость кашлевого центра.
Фармакологическое действие

Противокашлевое средство центрального действия; алкалоид фенантренового ряда. Агонист опиатных рецепторов, уменьшает возбудимость кашлевого центра. Центральный противокашлевой эффект связан с подавлением кашлевого центра.
Побочные эффекты
Со стороны пищеварительной системы
Более часто — запор;
Менее.......паралитическая кишечная непроходимость,
частота неизвестна — увеличение или снижение массы тела;

При передозе:
Лечение

Промывание желудка, восстановление дыхания и поддержание сердечной деятельности и артериального давления; внутривенное введение специфического антагониста опиоидных анальгетиков — налоксона.

[Igor_Passau]

2007

CONCLUSIONS: LDN therapy appears effective and safe in subjects with active Crohn's disease. Further studies are needed to explore the use of this compound
http://www.ncbi.nlm.nih.gov/pubmed/17222320

[Igor_Passau]

ну а тут вообще
http://www.lowdosenaltrexone.org/

[Igor_Passau]

http://www.expert-reviews.com/doi/pd...1586/egh.11.62

Strategies that upregulate the function of the opioid growth factor–opioid growth factor receptor system, such as low-dose naltrexone, hold considerable promise in designing new biological-based treatments that are efficacious, nontoxic, inexpensive and orally delivered

[Igor_Passau]

читайте о моем опыте:
http://kronportal.ru/forum/showthread.php/3399-Р˜СЃС‚РѕСЂРёСЏ-Igor_Passau/page80

[Igor_Passau]

Детали с сайта в США о налтрексоне:

When I started, the nearest pharmacy that the lowdosenaltrexone site listed in Canada was in Toronto. I was prepared to go that route, but there is the possibility of a missed shipment... so I was really glad AND eternally grateful my doctor convinced a local pharma to compound it. Any pharmacy equipped with a hood (Naltrexone is sold in bulk in powder form, and since it is a neurologic, it has to be done at a site with proper ventilation) SHOULD be able to compound it. Your typical drug store/pharmacy is rarely equipped like that. But if they are, then there is no reason you can't source it locally. Unless they don't put in the effort to find out how to compound it properly. Halifax is a relatively small city in an relatively small province, but we now have 2 pharmacies that do compound it (LDN). Keep in mind that Crohns isn't the only disease this drug (in special compounds) is being used for. Both pharmacies here were able to get all the info they needed to do it right.
If you go this route, there are pitfalls to avoid... like the pharmacy doesn't do their work in researching this and compounds Naltrexone SR instead of Naltrexone (SR won't work). A percentage of people are sensitive to the filler/binder used in compounding. Lactose is a common one... no problem if you aren't sensitive, big problem if you are. Some places will offer a choice of fillers.... avicel (sp?), acidophilus (even more sp???) AND a choice of the type of capsule... glycerin, cellulose, etc (I'm not a pharmacist, so anyone with more info feel free to jump in).. I'm lactose sensitive, so I've always specified none in my pills, but I've never had issue with any of the other combos of fillers and capsules. But that is just my case. (issues like that, any given patient being sensitive to common pill components/fillers/etc. CAN crop up at any pharmacy). So, if your child has displayed reaction or allergy type issues with other meds (even flares) then you might want to look into it AND your options. Be a downright shame to get approval for LDN only to have issues (including flare like issues) stemming from something as innocent looking as the filler or capsule. I believe (but don't hold me to it) there was a member who was very sensitive to acidolphilous. Like I am to lactose. You never know this till it happens.

Couple of other points... When I first researched LDN (at lowdosenaltrexone forum) they were advising folks that candida can hinder the effectiveness of LDN. And that looking in ones saliva for long strands was a good indicator IF one was plagued with overabundant candida... (which may be alleviated by acidolphilous).. Anyway, if going the LDN route, do the saliva check. And, LDN is not approved for treating Crohns, there is no 4.5 mg pill available from the manufacturer, so there is no DIN associated with it.. which means I know of no insurance company/plan that will cover the cost of meds with no official DIN.

Т.е. Замедленного действия не работает! При кандите тоже не работает!

[Igor_Passau]

I would heartily suggest to anyone considering LDN not to throw in the towel without going on the 4.5 mg dosage for 12 - 14 weeks minimum. And, if you do go on it, and your symptoms increase in severity, I would still strongly urge you to try to hold out for that same period of time. Whether Naltrexone suppresses your immune response, or causes it to reset, or creates just a temporary rebound effect (how it works depends on who you listen to, and I'm not sure anyone knows exactly how it does what it does) the thing of it is that, in and of itself... it doesn't attack your IBD directly. To try to clarify (and bear in mind I'm strictly a layman here, no medical training of any kind to back this up)... imagine... your disease suddenly isn't presented with the typical meds that are used to try to halt its progress. It's like a holiday... and it will probably want to party. Slowly, gradually, the Naltrexone gives your body a fighting chance to put the disease in its place... then the battle really begins. And, for a large percentage of people who have tuffed it out, LDN will stop IBD. And continue to do so with no dangerous effects to worry about in the long term (at least none known so far, and I've got almost 4 1/2 years of experience to back up that statement). If, after 12 - 14 weeks, you've seen no improvement, then either 4.5 mg of LDN isn't going to work for you, or it wasn't the right type or dosage, or you've had other issues... like candida overgrowth, that got in the way. That is the gamble, and it isn't to be taken lightly. But, if you hit the jackpot then you're laughing. Seriously. Pre LDN, I was lucky to get a... reprieve.. remission.. that lasted a week or two tops. I never imagined that LDN would keep me going as long as it had. From what I was told, many other meds with all those complications typically only worked 2 - 3 years before results plummeted. And they still created side effects to keep one up nights. I'm dealing with that now from my trials on AZA. And it ain't nice.