Туберкулёз, псевдотуберкулёз (Mycobacterium avium subspecies paratuberculosis) и ВЗК

[Вася Пупкин]

Я вот не совсем понял причем тут паратуберкулез!?Если это болезнь животных....

А что до этого было и есть мало опасных для человека болезней , переносчики которых животные ?

Извини Proba что в твоей теме зацепелись.

[v1tek1992]

А что до этого было и есть мало опасных для человека болезней , переносчики которых животные ?

Извини Proba что в твоей теме зацепелись.

Таких болезней в избытке! Но среди них нет паратуберкулеза, есть псевдотуберкулез...Думаю пора заканчивать с этим, ведь сколько людей столько и мнений...Да и тема не соответствующая!

[Вася Пупкин]

Напомню ссылку на конференцию в США по МАР ( 2007году, опубликовано в 2008г.), в Академии Микробиологии:
http://www.cureforcrohns.co.uk/MAP.pdf

[Вася Пупкин]

Вот как это сделать ? И получается находили и не раз?

У иммуноскомпрометированных больных следует убедиться в отсутствии цитомегаловируса, вирусов герпеса, Mycobacterium avium-intracellulare.

http://health-ua.com/articles/1449.html
Неспецифический язвенный колит: современное состояние проблемы
Т.Д. Звягинцева, д.м.н., профессор, С.В. Гриднева; Харьковская медицинская академия последипломного образования

[387676]

Вася МАС (атипичные микобактерии) одна из основным причин смерти больных спидом. Их прекрасно высевают на Бактеке. ПРосто мы о разных вещах говорим. Ты только о паратуберкулезис, я об атипии вообще, которую можно уложить в понятие MAC (avium complex)

[Igor_Passau]

Bacteria might be involved in the development and persistence of inflammation in patients with Crohn's disease, and antibiotics could be used in therapy.
Dr Cosimo Prantera and colleagues from Italy performed a clinical phase 2 trial to determine whether a gastroresistant formulation of rifaximin induced remission in patients with moderately active Crohn's disease.
The research team performed a multicenter, randomized, double-blind trial of the efficacy and safety of 400, 800, and 1200 mg rifaximin-extended intestinal release, given twice daily to 402 patients with moderately active CD for 12 weeks.
Data from patients given rifaximin-extended intestinal release were compared with those from individuals given placebo, and collected during a 12-week follow-up period.
The team's primary end point was remission at the end of the treatment period.


Remission was achieved by 54% of the patients given the 400-mg dose

At the end of the 12-week treatment period, 62% of patients who received the 800-mg dosage of rifaximin-extended intestinal release were in remission, compared with 43% of patients who received placebo.
The team observed that a difference was maintained throughout the 12-week follow-up period.
Remission was achieved by 54% and 47% of the patients given the 400-mg and 1200-mg dosages of rifaximin-extended intestinal release, respectively.
These rates did not differ from those of placebo.
The team found that patients given the 400-mg and 800-mg dosages of rifaximin-extended intestinal release had low rates of withdrawal from the study because of adverse events.
The team noted that withdrawal rates were significantly higher among patients given the 1200-mg dosage.
Dr Prantera's team concludes, "Administration of 800 mg rifaximin-extended intestinal release twice daily for 12 weeks induced remission with few adverse events in patients with moderately active Crohn's disease."



http://www.gastrohep.com/news/news.asp?id=108664

[jama]

Интересно по какой схеме они принимали в течение этих 12 недель. В инструкции продолжительность лечения не более 7 дней и повторный курс не ранее, чем 20-40 дней.

[Sonechka_99]

Еще в сентябре прошлого года врач мне назначила такой курс. Мне хватило денег только на 4 недели. В ремиссию не вышла.

[Igor_Passau]

Doctors who treat patients with Crohn’s disease have long regarded the illness
as a biological version of friendly fire, where people’s own immune systems
mistakenly attack the digestive tract. But Washington State University
researcher William Davis said its cause may originate outside the human body -
from a germ that sickens cattle.

Working with scientists internationally,
Davis is developing a vaccine that could head off the problem.


In
2006, the U.S. Department of Agriculture issued a fact sheet acknowledging
researchers’ concerns that MAP is being transmitted to humans in undercooked
meat, unpasteurized milk and water.

In 2008, a report by the American
Academy of Microbiology said that people with Crohn’s disease are "seven-fold
more likely” to have MAP in their gut tissues. While the cause of Crohn’s is
unknown, the authors wrote, "the possible role of this bacterium, which could
conceivably be passed up the food chain to people, has received too little
attention from the research community.”

More precise testing tools reveal
MAP is present in healthy humans as well, said Davis – a finding that "tells us
that all humans are susceptible to MAP infection but that its presence doesn’t
always lead to disease. While not destroying MAP, the human immune system is
keeping it in check.”

Skeptics insist that MAP be consistently found in
all Crohn's patients before they will consider it as a potential cause of the
disease, according to medical literature critical of the MAP-link theory. But
physician and researcher William Chamberlin - who sees Crohn’s patients almost
daily - doesn’t need that kind of evidence, he said.

"This is a classic case of the 800 pound gorilla in the living
room that’s easier to ignore than to do something about,” said Chamberlin, a
gastroenterologist who, in 2011, co-authored a review in the journal Clinical
Immunology concluding that Crohn’s is caused by infections, not an autoimmune
disorder.


Backing the 2008 report by the American Academy of
Microbiology suggesting that Crohn’s isn’t a single disease but a syndrome with
different causes, "MAP is but one of them,” said Chamberlin in an
interview.

He likens the MAP controversy to the one that ensued over the
link between H. pylori and stomach ulcers 30 years ago. Doctors entrenched in
the belief that stress and spicy foods caused ulcers resisted an Australian
physician’s evidence that the real culprit was a bacterial
infection.

Desperate to prove his point, the physician drank a test tube
of the bacteria and swiftly developed an ulcer. Then, instead of using the
customary antacids to treat it, he took antibiotics – today considered the
standard treatment for most stomach ulcers.

And so, as science moves in
fits and starts and skepticism continues to percolate, Davis will soon enter his
third decade of MAP research on cattle."
http://www.youtube.com/watch?feature...&v=ISPLWDgU0Xg

[Igor_Passau]

2012
MAP in Crohn patients in Italy hospital. Found in
the tap water.

---

In hospitals where multiple specimens were obtained
from different sites in the intestine, the prevalence of Mycobacterium avium
subspecies paratuberculosis infection was 82.1% and 40%
respectively in Crohn's disease and ulcerative colitis
patients; in another hospital, where single specimens were obtained from
patients, the bacterium was not detected. Control subjects also harboured
Mycobacterium avium subspecies paratuberculosis, but at a lower prevalence.
Tap water samples collected in the study area contained
Mycobacterium avium subspecies paratuberculosis DNA.


http://www.ncbi.nlm.nih.gov/pubmed/22285147