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  1. #441
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    23.09.2010
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  2. #442
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  3. #443
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    23.09.2010
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    Uncanny similarity of unique inserts in the 2019-nCoV spike protein to HIV-1 gp120 and Gag
    Abstract

    We are currently witnessing a major epidemic caused by the 2019 novel coronavirus (2019- nCoV). The evolution of 2019-nCoV remains elusive. We found 4 insertions in the spike glycoprotein (S) which are unique to the 2019-nCoV and are not present in other coronaviruses. Importantly, amino acid residues in all the 4 inserts have identity or similarity to those in the HIV-1 gp120 or HIV-1 Gag. Interestingly, despite the inserts being discontinuous on the primary amino acid sequence, 3D-modelling of the 2019-nCoV suggests that they converge to constitute the receptor binding site. The finding of 4 unique inserts in the 2019-nCoV, all of which have identity /similarity to amino acid residues in key structural proteins of HIV-1 is unlikely to be fortuitous in nature. This work provides yet unknown insights on 2019-nCoV and sheds light on the evolution and pathogenicity of this virus with important implications for diagnosis of this virus.
    https://www.biorxiv.org/content/10.1...01.30.927871v1
    -------
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    29.01.2020 - 08:49


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  4. #444
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    23.09.2010
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