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  1. #11
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    22.08.2018
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    The role of Mycobacterium avium subspecies paratubercu-losis (MAP) has been debated for many years. A randomised placebo-controlled trial of 2 years therapy with clarithromycin, rifabutin and clofazimine in 213 patients with active Crohns disease, with a further year of follow-up, showed early benefit of antibiotics, but overall there was no significant difference in relapse rate during follow-up.444 There was debate about the dosage and formulation chosen, and the study design (with with-drawal of non-responders at week 16). A further phase 3 trial using higher doses was reported in October 2018.445 A total of 331 patients with moderate to severely active Crohns disease were randomised to RHB-104 (clarithromycin 95 mg, rifab-utin 45 mg and clofazimine 10 mg) five capsules twice daily or placebo for 52 weeks, in addition to their pre-study therapy. At week 26, remission was achieved in 37% versus 23% on placebo (p=0.007), and durable remission (from week 16 to 52) was achieved in 18% versus 9% on placebo (p=0.019). No data are available on endoscopic healing or on persistence of benefit after stopping treatment.
    "Pain is inevitable. Suffering is optional."
    Haruki Murakami
       

  2. #12
       

  3. #13
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    23.09.2010
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    "Pain is inevitable. Suffering is optional."
    Haruki Murakami
       

  6. #16
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    "Pain is inevitable. Suffering is optional."
    Haruki Murakami
       

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